Shamsi F#*, Zheng R#, Ho L-L, Chen K*, Tseng Y-H*. (2023) Comprehensive analysis of intercellular communication in thermogenic adipose niche. Communication Biology. PubMed #Equal contribution, *Corresponding author

Selected publications

Shamsi F. Methods for Single Cell Transcriptomic Analysis of Adipose Tissue. Methods Mol Biol. 2023;2662:241-249. PubMed

Shamsi F, Wang CH, Tseng YHT. (2021) The evolving view of thermogenic adipocytes — ontogeny, niche and function. Nature Reviews Endocrinology. PubMed

Shamsi F, Piper M, Ho LL, Huang TL, Gupta A, Streets A, Lynes MD, Tseng YH. (2021) Vascular smooth muscle-derived TRPV1-expressing progenitors are a source of cold-induced thermogenic adipocytes. Nature Metabolism. 3(4):485-495. PubMed

Featured in:

Nature Metabolism news & views "The genesis of brown fat- a smooth muscle origin story revisited." PubMed

Nature Reviews Endocrinology Research Highlight “Identification of thermogenic adipocyte lineages." PubMed

Angueira AR, Sakers AP, Holman CD, Cheng L, Arbocco M, Shamsi F, Lynes MD, Shrestha R, Okada C, Batmanov K, Susztak K, Tseng YH, Liaw L, Seale P. (2021) Defining the lineage of thermogenic perivascular adipose tissue. Nature Metabolism. 3(4):469-484. PubMed

Shamsi F, Tseng YH, Kahn CR. (2021) Adipocyte Microenvironment: Everybody in the Neighborhood Talks About the Temperature. Cell Metabolism, 33(1):4-6. PubMed

Wang CH, Lundh M, Fu A, Kriszt R, Huang TL, Lynes MD, Leiria LO, Shamsi F, Darcy J, Greenwood BP, Narain NR, Tolstikov V, Smith KL, Emanuelli B, Chang YT, Hagen S, Danial NN, Kiebish MA, Tseng YH. (2020) CRISPR-engineered human brown-like adipocytes prevent diet-induced obesity and ameliorate metabolic syndrome in mice. Science Translational Medicine. 26;12(558). PubMed

Shwartz Y, Gonzalez-Celeiro M, Chen CL, Pasolli HA, Sheu SH, Fan S, Shamsi F, Assaad S, Lin E, Zhang B, Tsai PC, He M, Tseng YH, Lin SJ, and Hsu YC. (2020) Cell types promoting goosebumps form a niche to regulate hair follicle stem cells. Cell, 182, 578–593. PubMed

Shamsi F, Xue R, Huang TL, Lundh M, Liu Y, Leiria LO, Lynes MD, Kempf E, Wang CH, Sugimoto S, Nigro P, Landgraf K, Schulz T, Li Y, Emanuelli B, Kothakota S,Williams LT, Jessen N, Pedersen SB, Böttcher Y, Blüher M, Körner A, Goodyear LJ, Mohammadi M, Kahn CR, Tseng YH. (2020) FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis. Nature Communications, 11(1):1421. PubMed

Leiria LO, Wang CH, Lynes MD, Yang K, Shamsi F, Sato M, Sugimoto S, Chen EY, Bussberg V, Narain NR, Sansbury BE, Darcy J, Huang TL, Kodani SD, Sakaguchi M, Rocha AL, Schulz TJ, Bartelt A, Hotamisligil GS, Hirshman MF, van Leyen K, Goodyear LJ, Blüher M, Cypess AM, Kiebish MA, Spite M, Tseng YH. (2019) 12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat. Cell Metabolism, 30(4):768-783. PubMed

Lynes MD, Shamsi F, Sustarsic EG, Leiria LO, Wang CH, Su SC, Huang TL, Gao F, Narain NR, Chen EY, Cypess AM, Schulz TJ, Gerhart-Hines Z, Kiebish MA, Tseng YH. (2018) Cold-Activated Lipid Dynamics in Adipose Tissue Highlights a Role for Cardiolipin in Thermogenic Metabolism. Cell Reports, 24(3):781-790. PubMed

Shamsi F, Zhang H, Tseng YH. (2017) MicroRNA Regulation of Brown Adipogenesis and Thermogenic Energy Expenditure. Frontiers in Endocrinology, 8:205. PubMed

Lynes MD, Leiria LO, Lundh M, Bartelt A, Shamsi F, Huang TL, Takahashi H, Hirshman MF, Schlein C, Lee A, Baer LA, May FJ, Gao F, Narain NR, Chen EY, Kiebish MA, Cypess AM, Bluher M, Goodyear LJ, Hotamisligil GS, Stanford KI, Tseng YH. (2017) The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue. Nature Medicine, 23(5):631-637. PubMed

Shamsi F, Tseng YH. (2017) Protocols for Generation of Immortalized Human Brown and White Preadipocyte Cell Lines. Methods Mol Biol, 1566:77-85. PubMed

Shamsi F, Parlatto R, Collombat P, Mansouri A. (2014) A genetic mouse model for progressive ablation and regeneration of insulin producing beta-cells. Cell Cycle, 13(24):3948-57. PubMed